Publications

(1)
Davis, H. J.; Häussinger, D.; Ward, T. R.; Okamoto, Y. A Visible-Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex. ChemCatChem 2020, 12 (18), 4512-4516. https://doi.org/10.1002/cctc.202000488.   edoc
(2)
Serrano-Plana, J.; Rumo, C.; Rebelein, J. G.; Peterson, R. L.; Barnet, M.; Ward, T. R. Enantioselective Hydroxylation of Benzylic C(sp; 3; )-H Bonds by an Artificial Iron Hydroxylase Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society 2020, 142 (24), 10617-10623. https://doi.org/10.1021/jacs.0c02788.   edoc | Open Access
(3)
Miller, K. R.; Paretsky, J. D.; Follmer, A. H.; Heinisch, T.; Mittra, K.; Gul, S.; Kim, I.-S.; Fuller, F. D.; Batyuk, A.; Sutherlin, K. D.; Brewster, A. S.; Bhowmick, A.; Sauter, N. K.; Kern, J.; Yano, J.; Green, M. T.; Ward, T. R.; Borovik, A. S. Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases. Inorganic Chemistry 2020, 59 (9), 6000-6009. https://doi.org/10.1021/acs.inorgchem.9b03791.   edoc
(4)
Sabatino, V.; Staub, D.; Ward, T. R. Synthesis of N-Substituted Indoles via Aqueous Ring-Closing Metathesis. Catalysis Letters 2020, n/a. https://doi.org/10.1007/s10562-020-03271-3.   
(5)
Wu, S.; Zhou, Y.; Gerngross, D.; Jeschek, M.; Ward, T. R. Chemo-Enzymatic Cascades to Produce Cycloalkenes from Bio-Based Resources. Nature Communications 2019, 10 (1), 5060. https://doi.org/10.1038/s41467-019-13071-y.   edoc | Open Access
(6)
Wu, S.; Zhou, Y.; Rebelein, J. G.; Kuhn, M.; Mallin, H.; Zhao, J.; Igareta, N. V.; Ward, T. R. Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin As Host for Artificial Metalloenzymes. Journal of the American Chemical Society 2019, 141 (40), 15869-15878. https://doi.org/10.1021/jacs.9b06923.   edoc | Open Access
(7)
Sabatino, V.; Rebelein, J. G.; Ward, T. R. "Close-to-Release": Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis. Journal of the American Chemical Society 2019, 141 (43), 17048-17052. https://doi.org/10.1021/jacs.9b07193.   edoc | Open Access
(8)
Bartolami, E.; Basagiannis, D.; Zong, L.; Martinent, R.; Okamoto, Y.; Laurent, Q.; Ward, T. R.; Gonzalez-Gaitan, M.; Sakai, N.; Matile, S. Diselenolane-Mediated Cellular Uptake: Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots. Chemistry - A European Journal 2019, 25 (16), 4047-4051. https://doi.org/10.1002/chem.201805900.   edoc | Open Access
(9)
Sabatino, V.; Ward, T. R. Aqueous Olefin Metathesis: Recent Developments and Applications. Beilstein Journal of Organic Chemistry 2019, 15, 445-468. https://doi.org/10.3762/bjoc.15.39.   edoc | Open Access
(10)
Davis, H. J.; Ward, T. R. Artificial Metalloenzymes: Challenges and Opportunities. ACS Central Science 2019, 5 (7), 1120-1136. https://doi.org/10.1021/acscentsci.9b00397.   edoc | Open Access
(11)
Guo, X.; Okamoto, Y.; Schreier, M. R.; Ward, T. R.; Wenger, O. S. Reductive Amination and Enantioselective Amine Synthesis by Photoredox Catalysis. European Journal of Organic Chemistry 2019, 2020 (10), 1288-1293. https://doi.org/10.1002/ejoc.201900777.   edoc | Open Access
(12)
Cheng, Y.; Zong, L.; Lopez-Andarias, J.; Bartolami, E.; Okamoto, Y.; Ward, T. R.; Sakai, N.; Matile, S. Cell-Penetrating Dynamic-Covalent Benzopolysulfane Networks. Angewandte Chemie International Edition 2019, 58 (28), 9522-9526. https://doi.org/10.1002/anie.201905003.   edoc | Open Access
(13)
Liang, A. D.; Serrano-Plana, J.; Peterson, R. L.; Ward, T. R. Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Enzymatic Cascades and Directed Evolution. Accounts of Chemical Research 2019, 52 (3), 585-595. https://doi.org/10.1021/acs.accounts.8b00618.   edoc | Open Access
(14)
Rebelein, J. G.; Cotelle, Y.; Garabedian, B.; Ward, T. R. Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase As Host Protein. ACS Catalysis 2019, 9 (5), 4173-4178. https://doi.org/10.1021/acscatal.9b01006.   edoc | Open Access
(15)
Keller, S. G.; Probst, B.; Heinisch, T.; Alberto, R.; Ward, T. R. Photo-Driven Hydrogen Evolution by an Artificial Hydrogenase Utilizing the Biotin-Streptavidin Technology. Helvetica Chimica Acta 2018, 101 (4), e1800036. https://doi.org/10.1002/hlca.201800036.   edoc | Open Access
(16)
Heinisch, T.; Schwizer, F.; Garabedian, B.; Csibra, E.; Jeschek, M.; Vallapurackal, J.; Pinheiro, V. B.; Marlière, P.; Panke, S.; Ward, T. R. E. Coli Surface Display of Streptavidin for Directed Evolution of an Allylic Deallylase. Chemical Science 2018, 9 (24), 5383-5388. https://doi.org/10.1039/c8sc00484f.   edoc | Open Access
(17)
Okamoto, Y.; Kojima, R.; Schwizer, F.; Bartolami, E.; Heinisch, T.; Matile, S.; Fussenegger, M.; Ward, T. R. A Cell-Penetrating Artificial Metalloenzyme Regulates a Gene Switch in a Designer Mammalian Cell. Nature Communications 2018, 9, 1943. https://doi.org/10.1038/s41467-018-04440-0.   edoc | Open Access
(18)
Christoffel, F.; Ward, T. R. Palladium-Catalyzed Heck Cross-Coupling Reactions in Water: A Comprehensive Review. Catalysis letters 2018, 148 (2), 489-511. https://doi.org/10.1007/s10562-017-2285-0.   edoc | Open Access
(19)
Zhao, J.; Rebelein, J. G.; Mallin, H.; Trindler, C.; Pellizzoni, M. M.; Ward, T. R. Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli’s Periplasm. Journal of American Chemical Society 2018, 140 (41), 13171-13175. https://doi.org/10.1021/jacs.8b07189.   edoc | Open Access
(20)
Mann, S.; Heinisch, T.; Ward, T. R.; Borovik, A. S. Coordination Chemistry Within a Protein Host: Regulation of the Secondary Coordination Sphere. Chemical Communications 2018, 54 (35), 4413-4416. https://doi.org/10.1039/c8cc01931b.   edoc | Open Access
(21)
Pellizzoni, M. M.; Schwizer, F.; Wood, C. W.; Sabatino, V.; Cotelle, Y.; Matile, S.; Woolfson , D. N.; Ward, T. R. Chimeric Streptavidins As Host Proteins for Artificial Metalloenzymes. ACS Catalysis 2018, 8 (2), 1476-1484. https://doi.org/10.1021/acscatal.7b03773.   edoc | Open Access
(22)
Mallin, H.; Ward, T. R. Streptavidin-Enzyme Linked Aggregates for the One-Step Assembly and Purification of Enzyme Cascades. ChemCatChem 2018, 10 (13), 2810-2816. https://doi.org/10.1002/cctc.201800162.   edoc | Open Access
(23)
Szponarski, M.; Schwizer, F.; Ward, T. R.; Gademann, K. On-Cell Catalysis by Surface Engineering of Live Cells With an Artificial Metalloenzyme. Communications Chemistry 2018, 1 (84), 1-10. https://doi.org/10.1038/s42004-018-0087-y.   edoc | Open Access
(24)
Hestericová, M.; Heinisch, T.; Alonso-Cotchico, L.; Maréchal, J.-D.; Vidossich, P.; Ward, T. R. Directed Evolution of an Artificial Imine Reductase. Angewandte Chemie - International Edition 2018, 57 (7), 1863-1868. https://doi.org/10.1002/anie.201711016.   edoc | Open Access
(25)
Hestericova, M.; Heinisch, T.; Lenz, M.; Ward, T. R. Ferritin Encapsulation of Artificial Metalloenzymes: Engineering a Tertiary Coordination Sphere for an Artificial Transfer Hydrogenase. Dalton transactions 2018, 47 (32), 10837-10841. https://doi.org/10.1039/c8dt02224k.   edoc | Open Access
(26)
Zhao, J.; Bachmann, D. G.; Lenz, M.; Gillingham, D. G.; Ward, T. R. An Artificial Metalloenzyme for Carbene Transfer Based on a Biotinylated Dirhodium Anchored Within Streptavidin. Catalysis science & technology 2018, 8 (9), 2294-2298. https://doi.org/10.1039/c8cy00646f.   edoc | Open Access
(27)
Guo, X.; Okamoto, Y.; Schreier, M. R.; Ward, T. R.; Wenger, O. S. Enantioselective Synthesis of Amines by Combining Photoredox and Enzymatic Catalysis in a Cyclic Reaction Network. Chemical Science 2018, 9, 5052-5056. https://doi.org/10.1039/C8SC01561A.   edoc | Open Access
(28)
Schwizer, F.; Okamoto, Y.; Heinisch, T.; Gu, Y.; Pellizzoni, M. M.; Lebrun, V.; Reuter, R.; Köhler, V.; Lewis, J. C.; Ward, T. R. Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. Chemical Reviews 2018, 118 (1), 142-231. https://doi.org/10.1021/acs.chemrev.7b00014.   edoc | Open Access
(29)
Rebelein, J. G.; Ward, T. R. In Vivo Catalyzed New-to-Nature Reactions. Current Opinion in Biotechnology 2018, 53, 106-114. https://doi.org/10.1016/j.copbio.2017.12.008.   edoc | Open Access
(30)
Jeschek, M.; Panke, S.; Ward, T. R. Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism. Trends in Biotechnology 2018, 36 (1), 60-72. https://doi.org/10.1016/j.tibtech.2017.10.003.   edoc | Open Access
(31)
Keller, S. G.; Pannwitz, A.; Mallin, H.; Wenger, O. S.; Ward, T. R. Streptavidin As a Scaffold for Light-Induced Long-Lived Charge Separation. Chemistry - A European Journal 2017, 23 (71), 18019-18024. https://doi.org/10.1002/chem.201703885.   edoc | Open Access
(32)
Mann, S.; Heinisch, T.; Ward, T. R.; Borovik, A. S. Peroxide Activation Regulated by Hydrogen Bonds Within Artificial Cu Proteins. Journal of the American Chemical Society 2017, 139 (48), 17289-17292. https://doi.org/10.1021/jacs.7b10452.   edoc | Open Access
(33)
Okamoto, Y.; Ward, T. R. Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH As Reductant in a Biochemical Context. Biochemistry 2017, 56 (40), 5223-5224. https://doi.org/10.1021/acs.biochem.7b00809.   edoc | Open Access
(34)
Okamoto, Y.; Ward, T. R. Supramolecular Enzyme Mimics. In Comprehensive Supramolecular Chemistry II; Atwood Ed., J., Ed.; Elsevier: Oxford, 2017; Vol. 4, pp. 459-510. https://doi.org/10.1016/B978-0-12-409547-2.12551-X.   edoc
(35)
Seck, C.; Mbaye, D. M.; Coufourier, S.; Lator, A.; Lohier, J.-F.; Poater, A.; Ward, T. R.; Gaillard, S.; Renaud, J.-L. Alkylation of Ketones Catalyzed by Bifunctional Iron Complexes: From Mechanistic Understanding to Application. ChemCatChem 2017, 9 (23), 4410-4416. https://doi.org/10.1002/cctc.201701241.   edoc
(36)
Okamoto, Y.; Ward, T. R. Cross-Regulation of an Artificial Metalloenzyme. Angewandte Chemie International Edition 2017, 56 (34), 10156-10160. https://doi.org/10.1002/anie.201702181.   edoc | Open Access
(37)
Trindler, C.; Ward, T. R. Artificial Metalloenzymes. In Effects of Nanoconfinement on Catalysis; Poli, R., Ed.; Springer: Cham, Switzerland, 2017; Vol. Fundamental and Applied Catalysis, pp. 49-82. https://doi.org/10.1007/978-3-319-50207-6_3.   edoc
(38)
Liu, L.; Cotelle, Y.; Klehr, J.; Sakai, N.; Ward, T. R.; Matile, S. Anion-π Catalysis: Bicyclic Products With Four Contiguous Stereogenic Centers from Otherwise Elusive Diastereospecific Domino Reactions on π-Acidic Surfaces. Chemical Science 2017, 8 (5), 3770-3774. https://doi.org/10.1039/C7SC00525C.   edoc | Open Access
(39)
Jeschek, M.; Bahls, M. O.; Schneider, V.; Marlière, P.; Ward, T. R.; Panke, S. Biotin-Independent Strains of Escherichia Coli for Enhanced Streptavidin Production. Metabolic Engineering 2017, 40, 33-40. https://doi.org/10.1016/j.ymben.2016.12.013.   edoc | Open Access
(40)
Jeschek, M.; Panke, S.; Ward, T. R. Periplasmic Screening for Artificial Metalloenzymes. Methods in enzymology 2016, 580, 539-556. https://doi.org/10.1016/bs.mie.2016.05.037.   edoc
(41)
Rottmann, P.; Ward, T. R.; Panke, S. Compartmentalization - A Prerequisite for Maintaining and Changing an Identity. Chimia 2016, 70 (6), 428-431. https://doi.org/10.2533/chimia.2016.428.   edoc | Open Access
(42)
Okamoto, Y.; Köhler, V.; Ward, T. R. An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades. Journal of the American Chemical Society 2016, 138 (18), 5782-5784. https://doi.org/10.1021/jacs.6b02470.   edoc | Open Access
(43)
Cotelle, Y.; Lebrun, V.; Sakai, N.; Ward, T. R.; Matile, S. Anion–π Enzymes. ACS Central Science 2016, 2 (6), 388-393. https://doi.org/10.1021/acscentsci.6b00097.   edoc | Open Access
(44)
Jeschek, M.; Reuter, R.; Heinisch, T.; Trindler, C.; Klehr, J.; Panke, S.; Ward, T. R. Directed Evolution of Artificial Metalloenzymes for in Vivo Metathesis. Nature 2016, 537 (7622), 661-665. https://doi.org/10.1038/nature19114.   edoc | Open Access
(45)
Jeschenk, M.; Panke, S.; Ward, T. R. Chapter Twenty-Three – Periplasmic Screening for Artificial Metalloenzymes. Methods in Enzymology 2016, 580, 539-556. https://doi.org/10.1016/bs.mie.2016.05.037.   edoc
(46)
Mann, S.; Heinisch, T.; Weitz, A. C.; Hendrich, M. R.; Ward, T. R.; Borovik, A. S. Modular Artificial Cupredoxins. Journal of the American Chemical Society 2016, 138 (29), 9073-9076. https://doi.org/10.1021/jacs.6b05428.   edoc
(47)
Hestericova, M.; Correro, M. R.; Lenz, M.; Corvini, P. F.-X.; Shahgaldian, P.; Ward, T. R. Immobilization of an Artificial Imine Reductase Within Silica Nanoparticles Improves Its Performance. Chemical Communications 2016, 52 (60), 9462-9465. https://doi.org/10.1039/C6CC04604E.   edoc | Open Access
(48)
Ward, T. R. Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C−C Bond-Forming Reactions. Angewandte Chemie International Edition 2016, 55 (48), 14909-14911. https://doi.org/10.1002/anie.201607222.   edoc | Open Access
(49)
Okamoto, Y.; Köhler, V.; Paul, C. E.; Hollmann, F.; Ward, T. R. Efficient In Situ Regeneration of NADH Mimics by an Artificial Metalloenzyme. ACS Catalysis 2016, 6 (6), 3553-3557. https://doi.org/10.1021/acscatal.6b00258.   edoc | Open Access
(50)
Heinisch, T.; Ward, T. R. Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Challenges and Opportunities. Accounts of Chemical Research 2016, 49 (9), 1711-1721. https://doi.org/10.1021/acs.accounts.6b00235.   edoc | Open Access
(51)
Chatterjee, A.; Mallin, H.; Klehr, J.; Vallapurackal, J.; Finke, A. D.; Vera, L.; Marsh, M.; Ward, T. R. An Enantioselective Artificial Suzukiase Based on the Biotin–Streptavidin Technology. Chemical Science 2016, 7 (1), 673-677. https://doi.org/10.1039/C5SC03116H.   edoc | Open Access
(52)
Hyster, T. K.; Ward, T. R. Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions. Angewandte Chemie International Edition 2016, 55 (26), 7344-7357. https://doi.org/10.1002/anie.201508816.   edoc | Open Access
(53)
Cotelle, Y.; Benz, S.; Avestro, A.-J.; Ward, T. R.; Sakai, N.; Matile, S. Anion-π Catalysis of Enolate Chemistry: Rigidified Leonard Turns As a General Tool to Run Reactions on Aromatic Surfaces. Angewandte Chemie International Edition 2016, 128 (13), 4347-4351. https://doi.org/10.1002/ange.201600831.   edoc | Open Access
(54)
Chatterjee, A.; Ward, T. R. Recent Advances in the Palladium Catalyzed Suzuki–Miyaura Cross-Coupling Reaction in Water. Catalysis Letters 2016, 146 (4), 820-840. https://doi.org/10.1007/s10562-016-1707-8.   edoc | Open Access
(55)
Mérel, D. S.; Gaillard, S.; Ward, T. R.; Renaud , J.-L. Achiral Cyclopentadienone Iron Tricarbonyl Complexes Embedded in Streptavidin: An Access to Artificial Iron Hydrogenases and Application in Asymmetric Hydrogenation. Catalysis Letters 2016, 146 (3), 564-569. https://doi.org/10.1007/s10562-015-1681-6.   edoc
(56)
Mallin, H.; Reuter, R.; Hestericova, M.; Ward, T. R. Library Design and Screening Protocol for Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Nature Protocols 2016, 11 (5), 835-852. https://doi.org/10.1038/nprot.2016.019.   edoc
(57)
Milopolska, E.; Kuss-Petermann, M.; Neuburger, M.; Wenger, O.; Ward, T. R. N-Heterocyclic Carbene Ligands Bearing a Naphthoquinone Appendage: Synthesis and Coordination Chemistry. Polyhedron 2016, 103, 261-266. https://doi.org/10.1016/j.poly.2015.04.019.   edoc
(58)
Liu, Z.; Lebrun, V.; Kitanosono, T.; Mallin, H.; Köhler, V.; Häussinger, D.; Hilvert, D.; Kobayashi, S.; Ward, T. R. Upregulation of an Artificial Zymogen by Proteolysis. Angewandte Chemie International Edition 2016, 55 (38), 11587-11590. https://doi.org/10.1002/anie.201605010.   edoc | Open Access
(59)
Keller, S. G.; Pannwitz, A.; Schwizer, F.; Klehr, J.; Wenger, O. S.; Ward, T. R. Light-Driven Electron Injection from a Biotinylated Triarylamine Donor to [Ru(diimine)3]2+-Labeled Streptavidin . Organic and Biomolecular Chemistry 2016, 14 (30), 7197-7201. https://doi.org/10.1039/C6OB01273F .   edoc | Open Access
(60)
Okamoto, Y.; Ward, T. R.; Wenger, O. S. From Photodriven Charge Accumulation to Fueling Enzyme Cascades in Molecular Factories. Chimia 2016, 70 (6), 395-397. https://doi.org/10.2533/chimia.2016.395.   edoc | Open Access
(61)
Cotelle, Y.; Chuard, N.; Lascano, S.; Lebrun, V.; Wehlauch, R.; Bohni, N.; Loercher, S.; Postupalenko, V.; Reddy, S. T.; Meier, W.; Palivan, C. G.; Gademann, K.; Ward, T. R.; Matile, S. Interfacing Functional Systems. Chimia 2016, 70 (6), 418-423. https://doi.org/10.2533/chimia.2016.418.   edoc | Open Access
(62)
Quinto, T.; Köhler, V.; Häussinger, D.; Ward, T. R. Artificial Metalloenzymes for the Diastereoselective Reduction of NAD+ to NAD2H. Organic and Biomolecular Chemistry 2015, 13, 357-360. https://doi.org/10.1039/C4OB02071E.   edoc | Open Access
(63)
Zhao, J.; Kajetanowicz, A.; Ward, T. R. Carbonic Anhydrase II As Host Protein for the Creation of a Biocompatible Artificial Metathesase. Organic and Biomolecular Chemistry 2015, 13 (20), 5652-5655. https://doi.org/ 10.1039/C5OB00428D.   edoc | Open Access
(64)
Heinisch, T.; Ward, T. R. Latest Developments in Metalloenzyme Design and Repurposing. European Journal of Inorganic Chemistry 2015, No. 21, 3406-3418. https://doi.org/10.1002/ejic.201500408.   edoc | Open Access
(65)
Reuter, R.; Ward, T. R. Profluorescent Substrates for the Screening of Olefin Metathesis Catalysts. Beilstein journal of organic chemistry 2015, 11, 1886-1892. https://doi.org/10.3762/bjoc.11.203.   edoc
(66)
Heinisch, T.; Pellizzoni, M.; Dürrenberger, M.; Tinberg, C. E.; Köhler, V.; Häussinger, D.; Klehr, J.; Baker, D.; Ward, T. R. Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design. Journal of the American Chemical Society 2015, 137 (32), 10414-10419. https://doi.org/10.1021/jacs.5b06622.   edoc | Open Access
(67)
Fujieda, N.; Schätti, J.; Stuttfeld, E.; Ohkubo, K.; Maier, T.; Fukuzumi, S.; Ward, T. R. Enzyme Repurposing of a Hydrolase As an Emergent Peroxidase Upon Metal Binding. Chemical Science 2015, 6 (7), 4060-4065. https://doi.org/10.1039/C5SC01065A.   edoc | Open Access
(68)
Reuter, R.; Ward, T. R. D(+)-Biotin. In e-EROS Encyclopedia of Reagents for Organic Synthesis; Fuchs, P., Bode, J., Charette, A., Rovis, T., Eds.; Wiley: London, UK, 2014; pp. 1-4. https://doi.org/10.1002/047084289X.rn01826.   edoc
(69)
Keller, S. G.; Ringenberg, M. R.; Häussinger, D.; Ward, T. R. Evaluation of the Formate Dehydrogenase Activity of Three-Legged Pianostool Complexes in Dilute Aqueous Solution. European Journal of Inorganic Chemistry 2014, 2014 (34), 5860-5864. https://doi.org/10.1002/ejic.201402348.   edoc
(70)
Kajetanowicz, A.; Chatterjee, A.; Reuter, R.; Ward, T. R. Biotinylated Metathesis Catalysts: Synthesis and Performance in Ring Closing Metathesis. Catalysis Letters 2014, 144 (3), 373-379.   edoc
(71)
Dürrenberger, M.; Ward, T. R. Recent Achievments in the Design and Engineering of Artificial Metalloenzymes. Current Opinion in Chemical Biology 2014, 19, 99-106. https://doi.org/10.1016/j.cbpa.2014.01.018.   edoc
(72)
Genz, M.; Köhler, V.; Krauss, M.; Singer, D.; Hoffmann, R.; Ward, T. R.; Sträter, N. An Artificial Imine Reductase Based on the RNAse S Scaffold. ChemCatChem 2014, 6 (3), 736-740. https://doi.org/10.1002/cctc.201300995.   edoc
(73)
Nogueira, E. S.; Schleier, T.; Dürrenberger, M.; Ballmer-Hofer, K.; Ward, T. R.; Jaussi, R. High-Level Secretion of Recombinant Full-Length Streptavidin in Pichia Pastoris and Its Application to Enantioselective Catalysis. Protein Expression and Purification 2014, 93, 54-63. https://doi.org/10.1016/j.pep.2013.10.015.   edoc
(74)
Quinto, T.; Köhler, V.; Ward, T. R. Recent Trends in Biomimetic NADH Regeneration. Topics in catalysis 2014, 57 (5), 321. https://doi.org/10.1007/s11244-013-0187-y.   edoc
(75)
Quinto, T.; Schwizer, F.; Zimbron, J. M.; Morina, A.; Köhler, V.; Ward, T. R. Expanding the Chemical Diversity in Artificial Imine Reductases Based on the Biotin-Streptavidin Technology. ChemCatChem 2014, 6 (4), 1010-1014. https://doi.org/10.1002/cctc.201300825.   edoc
(76)
Munoz-Robles, V.; Dürrenberger, M.; Tillmann, H.; Lledos, A.; Schirmer, T.; Ward, T. R.; Maréchal, J.-D. Structural, Kinetic, and Docking Studies of Artificial Imine Reductases Based on Biotin–Streptavidin Technology: An Induced Lock-and-Key Hypothesis. Journal of the American Chemical Society 2014, 136 (44), 15676-15683. https://doi.org/10.1021/ja508258t.   edoc
(77)
Wilson, Y. M.; Dürrenberger, M.; Nogueira, E. S.; Ward, T. R. Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts. Journal of the American Chemical Society 2014, 136 (25), 8928-8932. https://doi.org/10.1021/ja500613n.   edoc
(78)
Munoz-Robles, V.; Vidossich, P.; Lledos, A.; Ward, T. R.; Maréchal, J.-D. Computational Insights on an Artificial Imine Reductase Based on the Biotin–Streptavidin Technology. ACS Catalysis 2014, 4 (3), 833-842. https://doi.org/10.1021/cs400921n.   edoc
(79)
Ward, T. R. Author Profile: Thomas Ward. Angewandte Chemie International Edition 2013, 52 (18), 4722. https://doi.org/10.1002/anie.201208430.   edoc
(80)
Praneeth, V. K. K.; Ward, T. R. Metal-Catalyzed Organic Transformations Inside a Protein Scaffold Using Artificial Metalloenzymes. In Coordination Chemistry in Protein Cages: Principles, Design, and Applications; Wiley, 2013; Vol. 8, pp. 203-220.   edoc
(81)
Hamels, D. R.; Ward, T. R. Biomacromolecules As Ligands for Artificial Metalloenzymes. In Comprehensive Inorganic Chemistry II ; Elsevier, 2013; Vol. 6: Homogeneous Catalytic Applications, pp. 737-761. https://doi.org/10.1016/B978-0-08-097774-4.00626-4.   edoc
(82)
Schmid, M. H.; Ward, T. R.; Meuwly, M. Towards a Broadly Applicable Force Field for D6-Piano Stool Complexes. Journal of Chemical Theory and Computation 2013, 9 (5), 2313-2323. https://doi.org/10.1021/ct301080d.   edoc
(83)
Schwizer, F.; Köhler, V.; Dürrenberger, M.; Knörr, L.; Ward, T. R. Genetic Optimization of the Catalytic Efficiency of Artificial Imine Reductases Based on the Biotin-Streptavidin Technology. ACS Catalysis 2013, 3 (8), 1752-1755. https://doi.org/10.1021/cs400428r.   edoc
(84)
Monnard, F. W.; Nogueira, E. S.; Heinisch, T.; Schirmer, T.; Ward, T. R. Human Carbonic Anhydrase II As Host Protein for the Creation of Artificial Metalloenzymes : The Asymmetric Transfer Hydrogenation of Imines. Chemical Science 2013, 4 (6), 3269. https://doi.org/10.1039/C3SC51065D.   edoc | Open Access
(85)
Bereau, T.; Kramer, C.; Monnard, F. W.; Nogueira, E. S.; Ward, T. R.; Meuwly, M. Scoring Multipole Electrostatics in Condensed-Phase Atomistic Simulations. Journal of Physical Chemistry B 2013, 117 (18), 5460-5471. https://doi.org/10.1021/jp400593c.   edoc
(86)
Heinisch, T.; Langowska, K.; Tanner, P.; Reymond, J.-L.; Meier, W.; Palivan, C.; Ward, T. R. Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase Within a Biocompatible Compartment. ChemCatChem 2013, 5 (3), 720-723. https://doi.org/10.1002/cctc.201200834.   edoc
(87)
Zimbron, J. M.; Heinisch, T.; Schmid, M.; Hamels, D.; Nogueira, E. S.; Schirmer, T.; Ward, T. R. A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society 2013, 135 (14), 5384-5388. https://doi.org/10.1021/ja309974s.   edoc | Open Access
(88)
Koehler, V.; Wilson, Y. M.; Duerrenberger, M.; Ghislieri, D.; Churakova, E.; Quinto, T.; Knoerr, L.; Haeussinger, D.; Hollmann, F.; Turner, N. J.; Ward, T. R. Synthetic Cascades Are Enabled by Combining Biocatalysts With Artificial Metalloenzymes. Nature Chemistry 2013, 5 (2), 93-99. https://doi.org/10.1038/nchem.1498.   edoc
(89)
Hyster, T. K.; Knoerr, L.; Ward, T. R.; Rovis, T. Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation. Science 2012, 338 (6106), 500-503. https://doi.org/10.1126/science.1226132.   edoc
(90)
Oohora, K.; Burazerovic, S.; Onoda, A.; Wilson, Y. M.; Ward, T. R.; Hayashi, T. Chemically Programmed Supramolecular Assembly of Hemoprotein and Streptavidin With Alternating Alignment. Angewandte Chemie International Edition 2012, 51 (16), 3818-3821. https://doi.org/10.1002/anie.201107067.   edoc
(91)
Amrein, B.; Schmid, M.; Collet, G.; Cuniasse, P.; Gilardoni, F.; Seebeck, F. P.; Ward, T. R. Identification of Two-Histidines One-Carboxylate Binding Motifs in Proteins Amenable to Facial Coordination to Metals. Metallomics 2012, 4 (4), 379-388. https://doi.org/10.1039/C2MT20010D.   edoc
(92)
Praneeth, V. K. K.; Ringenberg, M. R.; Ward, T. R. Redox-Active Ligands in Catalysis. Angewandte Chemie International Edition 2012, 51 (41), 10228-10234. https://doi.org/10.1002/anie.201204100.   edoc
(93)
Schmid, M.; Nogueira, E. S.; Monnard, F. W.; Ward, T. R.; Meuwly, M. Arylsulfonamides As Inhibitors for Carbonic Anhydrase : Prediction & Validation. Chemical Science 2012, 3 (3), 690-700. https://doi.org/10.1039/C1SC00628B.   edoc | Open Access
(94)
Lo, C.; Ringenberg, M.; Gnandt, D.; Wilson, Y.; Ward, T. R. Artificial Metalloenzymes for Olefin Metathesis Based on the Biotin-(strept)avidin Technology. Chemical Communications 2011, 47 (44), 12065-12067. https://doi.org/10.1039/c1cc15004a.   edoc
(95)
Creus, M.; Ward, T. R. Design and Evolution of Artificial Metalloenzymes: Biomimetic Aspects. Progress In Inorganic Chemistry 2011, 57, 203-254. https://doi.org/10.1002/9781118148235.ch4.   edoc
(96)
Ward, T. R. Artificial Metalloenzymes Based on the Biotin-Avidin Technology : Enantio-Selective Catalysis and Beyond. Accounts of Chemical Research 2011, 44 (1), 47-57. https://doi.org/10.1021/ar100099u.   edoc
(97)
Dürrenberger, M.; Heinisch, T.; Wilson, Y.; Rossel, T.; Nogueira, E.; Knörr, L.; Mutschler, A.; Kersten, K.; Zimbron, M.; Pierron, J.; Schirmer, T.; Ward, T. R. Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines. Angewandte Chemie International Edition 2011, 50 (13), 3026-3029. https://doi.org/10.1002/anie.201007820.   edoc
(98)
Clemens, M.; Gillingham, D.; Ward, T. R.; Hilvert, D. An Artificial Metalloenzyme for Olefin Metathesis. Journal of the Chemical Society, Chemical Communications 2011, 47 (44), 12068-12070. https://doi.org/10.1039/c1cc15005g.   edoc
(99)
Köhler, V.; Mao, J.; Heinisch, T.; Pordea, A.; Sardo, A.; Wilson, Y.; Knörr, L.; Creus, M.; Prost, J.-C.; Schirmer, T.; Ward, T. R. OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective Cis-Dihydroxylation of Olefins. Angewandte Chemie International Edition 2011, 50 (46), 10863-10866. https://doi.org/10.1002/anie.201103632.   edoc
(100)
Ringenberg, M.; Ward, T. R. Merging the Best of Two Worlds : Artificial Metalloenzymes for Enantioselective Catalysis. Chemical Communications 2011, 47, (30), 8470-8476. https://doi.org/10.1039/c1cc11592h.   edoc
(101)
Sardo, A.; Wohlschlager, T.; Lo, C.; Zoller, H.; Ward, T. R.; Creus, M. Burkavidin: A Novel Secreted Biotin-Binding Protein from the Human Pathogen Burkholderia Pseudomallei. Protein Expression and Purification 2011, 77 (2), 131-139. https://doi.org/10.1016/j.pep.2011.01.003.   edoc
(102)
Monnard, F. W.; Heinisch, T.; Nogueira, E. S.; Schirmer, T.; Ward, T. R. Human Carbonic Anhydrase II As a Host for Piano-Stool Complexes Bearing a Sulfonamide Anchor. Chemical Communications 2011, 47 (29), 8238-8240. https://doi.org/10.1039/c1cc10345h .   edoc
(103)
Panek, J. J.; Ward, T. R.; Jezierska-Mazzarello, A.; Novic, M. Flexibility of a Biotinylated Ligand in Artificial Metalloenzymes Based on Streptavidin-an Insight from Molecular Dynamics Simulations With Classical and Ab Initio Force Fields. Journal of Computer-Aided Molecular Design 2010, 24 (9), 719-732. https://doi.org/10.1007/s10822-010-9369-x.   edoc
(104)
Heinisch, T.; Ward, T. R. Design Strategies for the Creation of Artificial Metalloenzymes. Current Opinion in Chemical Biology 2010, 14 (2), 184-199. https://doi.org/10.1016/j.cbpa.2009.11.026.   edoc
(105)
Koehler, V.; Ward, T. R. Design of a Functional Nitric Oxide Reductase Within a Myoglobin Scaffold. Chembiochem : a European journal of chemical biology 2010, 118 (8), 81049-81051. https://doi.org/10.1002/cbic.201000093.   edoc | Open Access
(106)
Koehler, V.; Wilson, Y. M.; Lo, C.; Sardo, A.; Ward, T. R. Protein-Based Hybrid Catalysts-Design and Evolution. Current Opinion in Biotechnology 2010, 21 (6), 744-752. https://doi.org/10.1016/j.copbio.2010.09.004.   edoc
(107)
Pordea, A.; Creus, M.; Letondor, C.; Ivanova, A.; Ward, T. R. Improving the Enantioselectivity of Artificial Transfer Hydrogenases Based on the Biotin-Streptavidin Technology by Combinations of Point Mutations. Inorganica Chimica Acta 2010, 363 (3), 601-604. https://doi.org/10.1016/j.ica.2009.02.001.   edoc
(108)
Zimbron, J. M.; Sardo, A.; Heinisch, T.; Wohlschlager, T.; Gradinaru, J.; Massa, C.; Schirmer, T.; Creus, M.; Ward, T. R. Chemo-Genetic Optimization of DNA Recognition by Metallodrugs Using a Presenter-Protein Strategy. Chemistry - A European Journal 2010, 16 (43), 12883-12889. https://doi.org/10.1002/chem.201001573.   edoc
(109)
Pordea, A.; Ward, T. R. Artificial Metalloenzymes : Combining the Best Features of Homogeneous and Enzymatic Catalysis. Synlett 2009, 2009 (16), 3225-3236. https://doi.org/10.1055/s-0029-1218305.   edoc
(110)
Fuerstenberg, A.; Kel, O.; Gradinaru, J.; Ward, T. R.; Emery, D.; Bollot, G.; Mareda, J.; Vauthey, E. Site-Dependent Excited-State Dynamics of a Fluorescent Probe Bound to Avidin and Streptavidin. ChemPhysChem 2009, 10 (9/10), 1517-1532. https://doi.org/10.1002/cphc.200900132.   edoc
(111)
Pordea, A.; Mathis, D.; Ward, T. R. IIncorporation of Biotinylated Manganese-Salen Complexes into Streptavidin: New Artificial Metalloenzymes for Enantioselective Sulfoxidation. Journal of Organometallic Chemistry 2009, 694 (6), 930-936. https://doi.org/10.1016/j.jorganchem.2008.11.023.   edoc
(112)
Panek, J. J.; Ward, T. R.; Jezierska, A.; Novic, M. Effects of Tryptophan Residue Fluorination on Streptavidin Stability and Biotin-Streptavidin Interactions via Molecular Dynamics Simulations. Journal of Molecular Modeling 2009, 15 (3), 257-266. https://doi.org/10.1007/s00894-008-0382-0.   edoc
(113)
Pordea, A.; Ward, T. R. Chemogenetic Protein Engineering : An Efficient Tool for the Optimization of Artificial Metalloenzymes. Chemical Communications 2008, 44 (36), 4239-4249. https://doi.org/10.1039/B806652C.   edoc
(114)
Pierron, J.; Malan, C.; Creus, M.; Gradinaru, J.; Hafner, I.; Ivanova, A.; Sardo, A.; Ward, T. R. Artificial Metalloenzymes for Asymmetric Allylic Alkylation on the Basis of the Biotin-Avidin Technology. Angewandte Chemie International Edition 2008, 47 (4), 701-705. https://doi.org/10.1002/anie.200703159.   edoc
(115)
Ward, T. R. Artificial Enzymes Made to Order : Combination of Computational Design and Directed Evolution. Angewandte Chemie International Edition 2008, 47 (41), 7802-7803. https://doi.org/10.1002/anie.200802865.   edoc
(116)
Han, A.; Creus, M.; Schuermann, G.; Linder, V.; Ward, T. R.; de Rooij, N. F.; Staufer, U. Label-Free Detection of Single Protein Molecules and Protein-Protein Interactions Using Synthetic Nanopores. Analytical Chemistry 2008, 80 (12), 4651-4658. https://doi.org/10.1021/ac7025207.   edoc
(117)
Creus, M.; Pordea, A.; Rossel, T.; Sardo, A.; Letondor, C.; Ivanova, A.; LeTrong, I.; Stenkamp, R. E.; Ward, T. R. X-Ray Structure and Designed Evolution of an Artificial Transfer Hydrogenase. Angewandte Chemie International Edition 2008, 47 (8), 1400-1404. https://doi.org/10.1002/anie.200704865.   edoc
(118)
Steinreiber, J.; Ward, T. R. Artificial Metalloenzymes As Selective Catalysts in Aqueous Media. Coordination Chemistry Reviews 2008, 252 (5-7), 751-766. https://doi.org/10.1016/j.ccr.2007.09.016.   edoc
(119)
Mao, J.; Ward, T. R. Artificial Metalloenzymes for Enantioselective Catalysis Based on the Biotin-Avidin Technology. Chimia 2008, 62 (12), 956-961. https://doi.org/10.2533/chimia.2008.956.   edoc | Open Access
(120)
Pordea, A.; Creus, M.; Panek, J.; Duboc, C.; Mathis, D.; Novic, M.; Ward, T. R. Artificial Metalloenzyme for Enantioselective Sulfoxidation Based on Vanadyl-Loaded Streptavidin. Journal of the American Chemical Society 2008, 130 (25), 8085-8088. https://doi.org/10.1021/ja8017219.   edoc
(121)
Creus, M.; Ward, T. R. Designed Evolution of Artificial Metalloenzymes: Protein Catalysts Made to Order. Organic and Biomolecular Chemistry 2007, 5 (12), 1835-1844. https://doi.org/10.1039/B702068F.   edoc
(122)
Burazerovic, S.; Gradinaru, J.; Pierron, J.; Ward, T. R. Hierarchical Self-Assembly of One-Dimensional Streptavidin Bundles As a Collagen Mimetic for the Biomineralization of Calcite. Angewandte Chemie International Edition 2007, 46 (29), 5510-5514. https://doi.org/10.1002/anie.200701080.   edoc
(123)
Mazurek, S.; Ward, T. R.; Novic, M. Counter Propagation Artificial Neural Networks Modeling of an Enantioselectivity of Artificial Metalloenzymes. Molecular Diversity 2007, 11 (3-4), 141-152. https://doi.org/10.1007/s11030-008-9068-x.   edoc
(124)
Rusbandi, U. E.; Lo, C.; Skander, M.; Ivanova, A.; Creus, M.; Humbert, N.; Ward, T. R. Second Generation Artificial Hydrogenases Based on the Biotin-Avidin Technology: Improving Activity, Stability and Selectivity by Introduction of Enantiopure Amino Acid Spacers. Advanced Synthesis and Catalysis 2007, 349 (11/12), 1923-1930. https://doi.org/10.1002/adsc.200700022.   edoc
(125)
Rusbandi, U. E.; Skander, M.; Ivanova, A.; Malan, C.; Ward, T. R. Second-Generation Artificial Hydrogenases Based on the biotin–avidin Technology: Improving Selectivity and Organic Solvent Tolerance by Introduction of an (R)-Proline Spacer. Comptes Rendus Chimie 2007, 10 (8), 678-683. https://doi.org/10.1016/j.crci.2007.02.020.   edoc
(126)
Letondor, C.; Pordea, A.; Humbert, N.; Ivanova, A.; Mazurek, S.; Novic, M.; Ward, T. R. Artificial Transfer Hydrogenases Based on the Biotin-(strept)avidin Technology : Fine Tuning the Selectivity by Saturation Mutagenesis of the Host Protein. Journal of the American Chemical Society 2006, 128 (25), 8320-8328. https://doi.org/10.1021/ja061580o.   edoc
(127)
Letondor, C.; Ward, T. R. Artificial Metalloenzymes for Enantioselective Catalysis: Recent Advances. ChemBioChem 2006, 7 (12), 1845-1852. https://doi.org/10.1002/cbic.200600264.   edoc
(128)
Delahaye, S.; Loosli, C.; Liu, S.-X.; Decurtins, S.; Labat, G.; Neels, A.; Loosli, A.; Ward, T. R.; Hauser, A. Inter- and Intramolecular Interactions in Some Supramolecular Photochemical Systems. Advanced Functional Materials 2006, 16 (2), 286-295. https://doi.org/10.1002/adfm.200500329.   edoc
(129)
Loosli, A.; Rusbandi, U. E.; Gradinaru, J.; Bernauer, K.; Schlaepfer, C. W.; Meyer, M.; Mazurek, S.; Novic, M.; Ward, T. R. (Strept)avidin As Host for Biotinylated Coordination Complexes:  Stability, Chiral Discrimination, and Cooperativity. Inorganic Chemistry 2006, 45 (2), 660-668. https://doi.org/10.1021/ic051405t.   edoc
(130)
Le Trong, I.; Humbert, N.; Ward, T. R.; Stenkamp, R. E. Crystallographic Analysis of a Full-Length Streptavidin With Its C-Terminal Polypeptide Bound in the Biotin Binding Site. Journal of Molecular Biology 2006, 356 (3), 738-745. https://doi.org/10.1016/j.jmb.2005.11.086.   edoc
(131)
Thomas, C. M.; Ward, T. R. Artificial Metalloenzymes: Proteins As Hosts for Enantioselective Catalysis . Chemical Society Reviews 2005, 34 (4), 337-346. https://doi.org/10.1039/B314695M.   edoc
(132)
Letondor, C.; Humbert, N.; Ward, T. R. Artificial Metalloenzymes Based on Biotin-Avidin Technology for the Enantioselective Reduction of Ketones by Transfer Hydrogenation. Proceedings of the National Academy of Sciences 2005, 102 (13), 4683-4687. https://doi.org/10.1073/pnas.0409684102.   edoc
(133)
Skander, M.; Malan, C.; Ivanova, A.; Ward, T. R. Chemical Optimization of Artificial Metalloenzymes Based on the Biotin-Avidin Technology : (S)-Selective and Solvent-Tolerant Hydrogenation Catalysts via the Introduction of Chiral Amino Acid Spacers. Chemical Communications 2005, 41 (38), 4815-4817. https://doi.org/10.1039/B509015F .   edoc
(134)
Thomas, C. M.; Letondor, C.; Humbert, N.; Ward, T. R. Aqueous Oxidation of Alcohols Catalyzed by Artificial Metalloenzymes Based on the Biotin-Avidin Technology. Journal of Organometallic Chemistry 2005, 690 (20), 4488-4491. https://doi.org/10.1016/j.jorganchem.2005.02.001.   edoc
(135)
Ward, T. R. Artificial Metalloenzymes for Enantioselective Catalysis Based on the Noncovalent Incorporation of Organometallic Moieties in a Host Protein. Chemistry - A European Journal 2005, 11 (13), 3798-3804. https://doi.org/10.1002/chem.200401232.   edoc
(136)
Thomas, C. M.; Ward, T. R. Design of Artificial Metalloenzymes. Applied Organometallic Chemistry 2005, 19 (1), 35-39. https://doi.org/10.1002/aoc.726.   edoc
(137)
Klein, G.; Humbert, N.; Gradinaru, J.; Ivanova, A.; Gilardoni, F.; Rusbandi, U. E.; Ward, T. R. Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology. Angewandte Chemie International Edition 2005, 44 (47), 7764-7767. https://doi.org/10.1002/anie.200502000.   edoc
(138)
Vieille-Petit, L.; Suess-Fink, G.; Therrien, B.; Ward, T. R.; Stoeckli-Evans, H.; Labat, G.; Karmazin-Brelot, L.; Neels, A.; Buergi, T.; Finke, R. G.; Hagen, C. M. Synthesis and Characterization of Tetrahedral Ru3O Clusters With Intrinsic Framework Chirality:  A Chiral Probe of the Intact Cluster Catalysis Concept. Organometallics 2005, 24 (25), 6104-6119. https://doi.org/10.1021/om050643t.   edoc
(139)
Humbert, N.; Zocchi, A.; Ward, T. R. Electrophoretic Behavior of Streptavidin Complexed to a Biotinylated Probe: A Functional Screening Assay for Biotin-Binding Proteins. Electrophoresis 2005, 26 (1), 47-52. https://doi.org/10.1002/elps.200406148.   edoc
(140)
Vieille-Petit, L.; Therrien, B.; Suss-Fink, G.; Ward, T. R. Erratum to “Isolation and Single-Crystal X-Ray Structure Analysis of the Catalyst-Substrate host–guest Complexes [C6H6⊂H3Ru3{C6H5(CH2)nOH}(C6Me6)2(O)]+ (n=2,3)” [J. Organomet. Chem. 684 (2003) 117–123]. Journal of Organometallic Chemistry, 2004, 689, 271. https://doi.org/10.1016/j.jorganchem.2003.11.002.   edoc
(141)
Suss-Fink, G.; Therrien, B.; Vieille-Petit, L.; Tschan, M.; Romakh, V. B.; Ward, T. R.; Dadras, M.; Laurenczy, G. Supramolecular Cluster Catalysis: Facts and Problems. Journal of Organometallic Chemistry 2004, 689 (8), 1362-1369. https://doi.org/10.1016/j.jorganchem.2003.12.032.   edoc
(142)
Collot, J.; Humbert, N.; Skander, M.; Klein, G.; Ward, T. R. Artificial Metalloenzymes for Enantioselective Catalysis : The Phenomenon of Protein Accelerated Catalysis. Journal of Organometallic Chemistry 2004, 689 (25), 4868-4871. https://doi.org/10.1016/j.jorganchem.2004.09.032.   edoc
(143)
Skander, M.; Humbert, N.; Collot, J.; Gradinaru, J.; Klein, G.; Loosli, A.; Sauser, J.; Zocchi, A.; Gilardoni, F.; Ward, T. R. Artificial Metalloenzymes:  (Strept)avidin As Host for Enantioselective Hydrogenation by Achiral Biotinylated Rhodium−Diphosphine Complexes. Journal of the American Chemical Society 2004, 126 (44), 14411-14418. https://doi.org/10.1021/ja0476718.   edoc
(144)
Zocchi, A.; Marya Jobe, A.; Neuhaus, J.-M.; Ward, T. R. Expression and Purification of a Recombinant Avidin With a Lowered Isoelectric Point in Pichia Pastoris. Protein Expression and Purification 2003, 32 (2), 167-174. https://doi.org/10.1016/j.pep.2003.09.001.   edoc
(145)
Vieille-Petit, L.; Therrien, B.; Suss-Fink, G.; Ward, T. R. Isolation and Single-Crystal X-Ray Structure Analysis of the catalyst–substrate host–guest Complexes [C6H6⊂H3Ru3{C6H5(CH2)nOH}(C6Me6)2(O)]+ (n=2, 3). Journal of Organometallic Chemistry 2003, 684 (1/2), 117-123. https://doi.org/10.1016/S0022-328X(03)00519-9.   edoc
(146)
Collot, J.; Gradinaru, J.; Humbert, N.; Skander, M.; Zocchi, A.; Ward, T. R. Artificial Metalloenzymes for Enantioselective Catalysis Based on Biotin-Avidin. Journal of the American Chemical Society 2003, 125 (30), 9030-9031. https://doi.org/10.1021/ja035545i.   edoc
(147)
Zocchi, A.; Humbert, N.; Berta, T.; Ward, T. R. Efficient Expression and Mutation of Avidin and Streptavidin As Host Proteins for Enantioselective Catalysis. Chimia 2003, 57 (10), 589-592.   edoc | Open Access
(148)
Ward, T. R.; Collot, J.; Gradinaru, J.; Loosli, A.; Skander, M.; Letondor, C.; Joseph, E.; Klein, G. Exploiting the Second Coordination Sphere : Proteins As Host for Enantioselective Catalysis. Chimia 2003, 57 (10), 586-588.   edoc | Open Access
(149)
Laurenczy, G.; Faure, M.; Vieille-Petit, L.; Suss-Fink, G.; Ward, T. R. Mechanistic in Situ High-Pressure NMR Studies of Benzene Hydrogenation by Supramolecular Cluster Catalysis With [(η6-C6H6)(η6-C6Me6)2Ru3(μ3-O)(μ2-OH)(μ2-H)2][BF4]. Advanced Synthesis and Catalysis 2002, 344 (10), 1073-1077. https://doi.org/10.1002/1615-4169(200212)344:103.0.CO;2-J .   edoc
(150)
Suss-Fink, G.; Faure, M.; Ward, T. R. Supramolecular Cluster Catalysis: Benzene Hydrogenation Catalyzed by a Cationic Triruthenium Cluster under Biphasic Conditions . Angewandte Chemie International Edition 2002, 41 (1), 99-101. https://doi.org/10.1002/1521-3773(20020104)41:13.0.CO;2-E .   edoc
(151)
Duclos, S.; Stoeckli-Evans, H.; Ward, T. R. Design and Synthesis of Compartmental Ligands and Their Complexes for the Production of Catalytic Antibodies. Helvetica Chimica Acta 2001, 84 (10), 3148-3161. https://doi.org/10.1002/1522-2675(20011017)84:103.0.CO;2-W .   edoc
(152)
Braendli, C.; Ward, T. R. A Versatile Approach to the Solution-Phase Combinatorial Synthesis of Substituted Pyridines:  The Cobalt-Catalyzed Cyclotrimerization of Alkynes With a Nitrile. Journal of Combinatorial Chemistry 2000, 2 (1), 42-47. https://doi.org/10.1021/cc9900450.   edoc
(153)
Therrien, B.; Ward, T. R. Synthesis of a Configurationally Stable Three-Legged Piano-Stool Complex. Angewandte Chemie International Edition 1999, 38 (3), 405-408. https://doi.org/10.1002/(SICI)1521-3773(19990201)38:33.0.CO;2-0.   edoc
(154)
Therrien, B.; Koenig, A.; Ward, T. R. Synthesis of a Configurationally Stable Three-Legged Piano-Stool Complex. Organometallics 1999, 18 (8), 1565-1568. https://doi.org/10.1021/om980949i.   edoc
(155)
Ward, T. R.; Lutz, A.; Parel, S. P.; Ensling, J.; Guetlich, P.; Buglyo, P.; Orvig, C. An Iron-Based Molecular Redox Switch As a Model for Iron Release from Enterobactin via the Salicylate Binding Mode. Inorganic Chemistry 1999, 38 (22), 5007-5017. https://doi.org/10.1021/ic990225e.   edoc
(156)
Ward, T. R. From Catalyst Design to Molecular Devices : Theory and Experiments. Chimia 1999, 53 (1/2), 19-28.   edoc | Open Access
(157)
Ward, T. R.; Duclos, S.; Therrien, B.; Schenk, K. Coordination Properties of Klaeui’s Tripodal Oxygen Donor Toward Zirconium(IV). Organometallics 1998, 17 (12), 2490-2494. https://doi.org/10.1021/om980088d.   edoc
(158)
Therrien, B.; Ward, T. R.; Pilkington, M.; Hoffmann, C.; Gilardoni, F.; Weber, J. Synthesis and Reactivity of Tethered η1:η6-(Phosphinoarene)ruthenium Dichlorides. Organometallics 1998, 17 (3), 330-337. https://doi.org/10.1021/om970735l.   edoc
(159)
Lutz, A.; Ward, T. R. Tripodal Dodecadentate Ligands With Salicylamide and Bipyridine Binding Sites for iron(II) and iron(III) Coordination. Helvetica Chimica Acta 1998, 81 (2), 207-218. https://doi.org/10.1002/hlca.19980810203.   edoc
(160)
Braendli, C.; Ward, T. R. Libraries via Metathesis of Internal Olefins. Helvetica Chimica Acta 1998, 81 (9), 1616-1621. https://doi.org/10.1002/(SICI)1522-2675(19980909)81:93.0.CO;2-P.   edoc
(161)
Gilardoni, F.; Weber, J.; Chermette, H.; Ward, T. R. Reactivity Indices in Density Functional Theory:  A New Evaluation of the Condensed Fukui Function by Numerical Integration. Journal of Physical Chemistry B 1998, 102 (20), 3607-3613. https://doi.org/10.1021/jp980521x.   edoc
(162)
Ward, T. R.; Schafer, O.; Daul, C.; Hofmann, P. Geometry of Coordinatively Unsaturated Two-Legged Piano Stool Complexes With 16 Valence Electrons:  A Theoretical Study. Organometallics 1997, 16 (14), 3207-3215. https://doi.org/10.1021/om9700369.   edoc
(163)
Ward, T. R.; Buergi, H.-B.; Gilardoni, F.; Weber, J. Edge-Bridged Tetrahedral Geometry of Five-Coordinate D0 Complexes, Relatives of the Bent [MCp2L3] Family:  A Theoretical and Structure-Correlation Study. Journal of the American Chemical Society 1997, 119 (49), 11974-11985. https://doi.org/10.1021/ja972230s.   edoc
(164)
Ward, T. R. Electronic Asymmetry : Theoretical Background, Ligand Design, and Applications. Chimia 1997, 51 (5), 238-240.   edoc | Open Access
(165)
Ward, T. R. Regioselectivity of Nucleophilic Attack on [Pd(allyl)(phosphine)(imine)] Complexes:  A Theoretical Study. Organometallics 1996, 15 (12), 2836-2838. https://doi.org/10.1021/om960158l.   edoc
(166)
Lutz, A.; Ward, T. R.; Albrecht, M. Synthesis of Salicylamide and Bipyridine Containing Ligands for iron(II) and iron(III) Coordination. Tetrahedron 1996, 52 (37), 12197-12208. https://doi.org/10.1016/0040-4020(96)00724-7.   edoc
(167)
Giannini, L.; Solari, E.; De Angelis, S.; Ward, T. R.; Floriani, C.; Chiesi-Villa, A.; Rizzoli, C. Migratory Aptitude of the Zr-C Functionalities Bonded to a Macrocyclic Structure : Thermally- and Solvent-Assisted Intra- and Intermolecular Migrations in dialkyl(dibenzotetramethyltetraazaannulene)zirconium(IV). Journal of the American Chemical Society 1995, 117 (21), 5801-5811.   edoc
(168)
Ward, T. R.; Alemany, P.; Hoffmann, R. Adhesion of Rh, Pd, and Pt to Alumina and NO Reactions on Resulting Surfaces. ACS Symposium Series 1994, 552, 140-156. https://doi.org/10.1021/bk-1994-0552.ch011.   edoc
(169)
Ward, T. R.; Hoffmann, R.; Shelef, M. Coupling Nitrosyls As the First Step in the Reduction of NO on Metal Surfaces : The Special Role of Rhodium. Surface science 1993, 289 (1-2), 85-99.   edoc
(170)
Ward, T. R.; Alemany, P.; Hoffmann, R. Adhesion of Rhodium, Palladium, and Platinum to Alumina and the Reduction of Nitric Oxide on the Resulting Surfaces: A Theoretical Analysis. The Journal of physical chemistry 1993, 97 (29), 7691-7699. https://doi.org/10.1021/j100131a044.   edoc
(171)
Imhof, D.; Rueegger, H.; Venanzi, L. M.; Ward, T. R. Solution Structure of [(triphos*)RhH2(AuPPh3)3][PF6]2 Deduced by One- and Two-Dimensional 1H{31P} and 1H{103Rh} Double-Resonance Techniques. Magnetic resonance in chemistry 1991, 29 (Spec. Issue), 73-79.   edoc
(172)
Ward, T. R.; Venanzi, L. M.; Albinati, A.; Lianza, F.; Gerfin, T.; Gramlich, V.; Ramos Tombo, G. M. Synthesis and X-Ray Crystal Structure of an Optically Pure Tripodal C3-Symmetric Tritertiary Phosphine Bearing Chirality on Phosphorus. Helvetica Chimica Acta 1991, 74 (5), 983-988.   edoc
(173)
Ott, J.; Schmid, B.; Venanzi, L. M.; Wang, G.; Ward, T. R.; Tombo, G. M. R. Rhodium Phosphine Complexes As Acetalization Catalysts. New Journal of Chemistry 1990, 14 (6-7), 495-498.   edoc
(174)
Ott, J.; Ramos Tombo, G. M.; Schmid, B.; Venanzi, L. M.; Wang, G.; Ward, T. R. A Versatile Rhodium Catalyst for Acetalization Reactions under Mild Conditions. Tetrahedron Letters 1989, 30 (45), 6151-6154. https://doi.org/10.1016/S0040-4039(01)93328-3.   edoc
(175)
Cornioley-Deuschel, C.; Ward, T. R.; Von Zelewsky, A. Complexes With Pincers : 2,6-Diphenylpyridine As Twofold-Deprotonated Terdentate Ligand in C,C-Trans-, and As Mono-Deprotonated Chelate Ligand in Chiral C,C-Cis-Complexes of platinum(II) and palladium(II). Helvetica Chimica Acta 1988, 71 (1), 130-133. https://doi.org/10.1002/hlca.19880710116.   edoc